2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121594
    GSK-269984B
    		Antagonist
    GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research.
    GSK-269984B
  • HY-P1020A
    Nocistatin(human) TFA
    		Inhibitor
    Nocistatin (human) TFA blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
    Nocistatin(human) TFA
  • HY-130594
    6α-Prostaglandin I1
    6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution.
    6α-Prostaglandin I1
  • HY-165587
    BM-573
    		Modulator
    BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator with an IC50 of 1.3 nM. BM-573 possesses both thromboxane synthase (TxAS) inhibition and thromboxane receptor (TP) antagonistic effects. BM-573 can completely inhibit platelet aggregation induced by Arachidonic acid (HY-109590) or U-46619 (TXA₂ analogues). BM-573 completely blocks the generation of TXB₂ (the stable metabolite of TXA₂) in human platelets and does not inhibit cyclooxygenase (COX-1/COX-2), thus avoiding interference with other prostaglandin synthesis. BM-573 has an inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle (ED₅₀ = 4.2 μM), but has no effect on contractions caused by PGE₂, PGF₂α, or PGI₂. BM-573 can be used in the study of atherosclerosis, myocardial infarction, pulmonary hypertension and shock.
    BM-573
  • HY-175077
    IP receptor antagonist 1
    		Antagonist
    CAY10449 is an I prostanoid receptor antagonist. CAY10449 can reverse iloprost-induced TEER reduction. CAY10449 can also reverse the effect of ONO-1301 in mouse model. CAY10449 can be studied in research on athsma and allergic airway inflammation.
    IP receptor antagonist 1
  • HY-116843
    (15S)-15-Methylprostaglandin E2
    		Agonist
    (15S)-15-Methylprostaglandin E2 ((15R)-15-Methyl-PGE) is a prostaglandin E2 analog with the potential to prevent gastrointestinal bleeding and protect gastrointestinal cells.
    (15S)-15-Methylprostaglandin E2
  • HY-B0131A
    Alprostadil sodium
    		Control
    Alprostadil sodium is a prostaglandin receptor ligand that exhibits Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in mice, respectively. It promotes vasodilation and inhibits platelet aggregation, making it a useful vasodilator for investigating peripheral vascular disease.
    Alprostadil sodium
  • HY-163091
    EP4 receptor antagonist 5
    		Antagonist
    EP4 receptor antagonist 5 is a potent and selective prostanoid EP4 receptor antagonist that can reduce inflammation Freund’s adjuvant (CFA) model.
    EP4 receptor antagonist 5
  • HY-117953
    RU 59063
    		Inhibitor 98.61%
    RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom.
    RU 59063
  • HY-B0191S1
    Bimatoprost-d4
    		Agonist
    Bimatoprost-d4 is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
    Bimatoprost-d<sub>4</sub>
  • HY-160844
    CT-133
    		Antagonist
    CT-133 is a selective and potent CRTH2 Receptor antagonist, with a Ki value of 2.2 nM. The Ki value for the DP1 receptor is greater than 3800 nM. CT-133 inhibits neutrophil migration induced by PGD2 (HY-101988). CT-133 significantly alleviates lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. CT-133 effectively inhibits the excessive expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (KC), and reverses the inhibition of the anti-inflammatory factor IL-10. CT-133 can be used for the study of ALI.
    CT-133
  • HY-117171
    Proquinazid
    		Inducer
    Proquinazid is a Bcl-2 and PCNA modulator, oxidative stress inducer, genotoxin and apoptosis inducer. Proquinazid causes DNA damage and also triggers apoptosis by regulating pro-apoptotic and anti-apoptotic proteins.
    Proquinazid
  • HY-N16733
    Deacetyltanghinin
    		Modulator
    Deacetyltanghinin is a selective inhibitor targeting Na+/K+ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na+/K+ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity.
    Deacetyltanghinin
  • HY-121091
    EP2 receptor agonist 4
    		Agonist
    EP2 receptor agonist 4 is a selective agonist for EP2 receptor with an EC50 of 43 nM.
    EP2 receptor agonist 4
  • HY-W746807
    Bimatoprost cyclohexyl amide
    		Agonist
    Bimatoprost cyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide) is an analog of bimatoprost (HY-B0191). Bimatoprost cyclohexyl amide is an agonist of the prostaglandin F2α receptor. Bimatoprost cyclohexyl amide is used in research on reducing intraocular pressure and glaucoma.
    Bimatoprost cyclohexyl amide
  • HY-19755
    S-5751
    		Antagonist
    S-5751 is an orally active prostaglandin DP receptor antagonist. S-5751 inhibits cAMP generation in platelet-rich plasma induced by PGD2 with IC50 0.12 μM. S-5751 has anti-inflammatory activity. S-5751 can be used in asthma research.
    S-5751
  • HY-108560S
    (+)-Fluprostenol-d4
    		Activator
    (+)-Fluprostenol-d4 is the deuterium labeled (+)-Fluprostenol (HY-108560). (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1).
    (+)-Fluprostenol-d<sub>4</sub>
  • HY-B0191A
    5,6-trans-Bimatoprost
    		Control
    5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
    5,6-trans-Bimatoprost
  • HY-116051
    16,16-Dimethylprostaglandin F2α
    16,16-Dimethylprostaglandin F2α (16,16-Dimethyl-PGF2α) is a potent analog of PGF2α (HY-12956), which exhibits similar binding potency as PGF2α does. 16,16-Dimethylprostaglandin F2α serves as a bronchoconstrictor.
    16,16-Dimethylprostaglandin F2α
  • HY-116250
    Prostaglandin D2-1-glyceryl ester
    		Agonist
    Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).
    Prostaglandin D2-1-glyceryl ester
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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